Assay Detail
Binding
CHEMBL824085
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of fibronectin binding to recombinant human alphaV-beta6 integrin
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Expert |
Publication
Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.58 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267434 | — | — | 1 | 10.40 |
| CHEMBL9278 | — | — | 1 | 9.82 |
| CHEMBL9200 | — | — | 1 | 9.40 |
| CHEMBL9555 | — | — | 1 | 9.22 |
| CHEMBL268056 | — | — | 1 | 8.77 |
| CHEMBL9737 | — | — | 1 | 8.40 |
| CHEMBL9508 | — | — | 1 | 7.36 |
| CHEMBL417066 | — | — | 1 | 7.28 |
| CHEMBL417426 | — | — | 1 | 7.21 |
| CHEMBL266151 | — | — | 1 | 6.34 |
| CHEMBL429876 | CILENGITIDE | 3.0 | 1 | 6.33 |
| CHEMBL2372398 | — | — | 1 | 6.28 |
| CHEMBL2372357 | — | — | 1 | 6.05 |
| CHEMBL2372331 | — | — | 1 | 5.62 |
| CHEMBL2372407 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267434 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL9278 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL9200 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL9555 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL268056 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL9737 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL9508 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL417066 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL417426 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL266151 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL429876 | CILENGITIDE | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL2372398 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL2372357 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2372331 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2372407 | — | IC50 | = | 6000.0 | nM | 5.22 |