Assay Detail
Binding
CHEMBL824111
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Inhibition of cyclic AMP-phosphodiesterase ( PDE) in the supernatant of tracheal muscle homogenate
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Muscle tissue |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 42 | 4.54 | 5.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29272 | — | — | 1 | 5.09 |
| CHEMBL32184 | — | — | 1 | 5.05 |
| CHEMBL286976 | — | — | 1 | 4.97 |
| CHEMBL283454 | — | — | 1 | 4.90 |
| CHEMBL282394 | — | — | 1 | 4.89 |
| CHEMBL27967 | — | — | 1 | 4.85 |
| CHEMBL29518 | — | — | 1 | 4.84 |
| CHEMBL28559 | — | — | 1 | 4.79 |
| CHEMBL28879 | — | — | 1 | 4.78 |
| CHEMBL27969 | — | — | 1 | 4.68 |
| CHEMBL28075 | — | — | 1 | 4.65 |
| CHEMBL28194 | — | — | 1 | 4.62 |
| CHEMBL288786 | — | — | 1 | 4.62 |
| CHEMBL157655 | — | — | 1 | 4.58 |
| CHEMBL28300 | — | — | 1 | 4.58 |
| CHEMBL29461 | — | — | 1 | 4.56 |
| CHEMBL283020 | — | — | 1 | 4.54 |
| CHEMBL28980 | — | — | 1 | 4.52 |
| CHEMBL282310 | — | — | 1 | 4.51 |
| CHEMBL283412 | — | — | 1 | 4.49 |
| CHEMBL31859 | — | — | 1 | 4.48 |
| CHEMBL287180 | — | — | 1 | 4.45 |
| CHEMBL628 | PENTOXIFYLLINE | 4.0 | 1 | 4.42 |
| CHEMBL32241 | — | — | 1 | 4.39 |
| CHEMBL279898 | ENPROFYLLINE | 2.0 | 1 | 4.37 |
| CHEMBL28683 | — | — | 1 | 4.34 |
| CHEMBL28603 | — | — | 1 | 4.33 |
| CHEMBL445847 | — | — | 1 | 4.31 |
| CHEMBL286741 | — | — | 1 | 4.28 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29272 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL32184 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL286976 | — | Ki | = | 10600.0 | nM | 4.97 |
| CHEMBL283454 | — | Ki | = | 12600.0 | nM | 4.90 |
| CHEMBL282394 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL27967 | — | Ki | = | 14100.0 | nM | 4.85 |
| CHEMBL29518 | — | Ki | = | 14600.0 | nM | 4.84 |
| CHEMBL28559 | — | Ki | = | 16400.0 | nM | 4.79 |
| CHEMBL28879 | — | Ki | = | 16500.0 | nM | 4.78 |
| CHEMBL27969 | — | Ki | = | 20700.0 | nM | 4.68 |
| CHEMBL28075 | — | Ki | = | 22300.0 | nM | 4.65 |
| CHEMBL288786 | — | Ki | = | 23800.0 | nM | 4.62 |
| CHEMBL28194 | — | Ki | = | 24100.0 | nM | 4.62 |
| CHEMBL157655 | — | Ki | = | 26100.0 | nM | 4.58 |
| CHEMBL28300 | — | Ki | = | 26200.0 | nM | 4.58 |
| CHEMBL29461 | — | Ki | = | 27300.0 | nM | 4.56 |
| CHEMBL283020 | — | Ki | = | 28700.0 | nM | 4.54 |
| CHEMBL28980 | — | Ki | = | 29900.0 | nM | 4.52 |
| CHEMBL282310 | — | Ki | = | 30800.0 | nM | 4.51 |
| CHEMBL283412 | — | Ki | = | 32300.0 | nM | 4.49 |
| CHEMBL31859 | — | Ki | = | 32800.0 | nM | 4.48 |
| CHEMBL287180 | — | Ki | = | 35800.0 | nM | 4.45 |
| CHEMBL628 | PENTOXIFYLLINE | Ki | = | 37700.0 | nM | 4.42 |
| CHEMBL32241 | — | Ki | = | 40800.0 | nM | 4.39 |
| CHEMBL279898 | ENPROFYLLINE | Ki | = | 43100.0 | nM | 4.37 |
| CHEMBL28683 | — | Ki | = | 46000.0 | nM | 4.34 |
| CHEMBL28603 | — | Ki | = | 46400.0 | nM | 4.33 |
| CHEMBL445847 | — | Ki | = | 48700.0 | nM | 4.31 |
| CHEMBL286741 | — | Ki | = | 53000.0 | nM | 4.28 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 56800.0 | nM | 4.25 |
| CHEMBL31838 | — | Ki | = | 56300.0 | nM | 4.25 |
| CHEMBL28419 | — | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL28298 | — | Ki | = | 72700.0 | nM | 4.14 |
| CHEMBL282160 | — | Ki | = | 92000.0 | nM | 4.04 |
| CHEMBL28684 | — | Ki | = | 92400.0 | nM | 4.03 |
| CHEMBL28295 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL281972 | — | Ki | = | 119000.0 | nM | - |
| CHEMBL29052 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL29209 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL27970 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL27915 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL283024 | — | Ki | = | 136000.0 | nM | - |