Assay Detail
Functional
CHEMBL824170
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Compound was tested for its inhibitory activity manca tumor cell growth
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Manca |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.71 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307486 | — | — | 1 | 8.00 |
| CHEMBL65616 | — | — | 1 | 7.58 |
| CHEMBL73267 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307486 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL65616 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL73267 | — | IC50 | = | 29.0 | nM | 7.54 |