Assay Detail
Binding
CHEMBL824372
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Inhibition of rat brain cytosolic cAMP phosphodiesterase
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.47 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19032 | PENTAMETHYLQUERCETIN | — | 1 | 5.20 |
| CHEMBL273765 | — | — | 1 | 5.00 |
| CHEMBL436338 | — | — | 1 | 4.70 |
| CHEMBL18262 | — | — | 1 | 4.46 |
| CHEMBL278972 | — | — | 1 | 4.43 |
| CHEMBL276918 | — | — | 1 | 4.40 |
| CHEMBL28079 | ZAPRINAST | 2.0 | 1 | 4.18 |
| CHEMBL18487 | — | — | 1 | 4.16 |
| CHEMBL18415 | — | — | 1 | 4.10 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.06 |
| CHEMBL18609 | — | — | 1 | - |
| CHEMBL19047 | — | — | 1 | - |
| CHEMBL19074 | PENTAACETYLQUERCETIN | — | 1 | - |
| CHEMBL18701 | RO-201724 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19032 | PENTAMETHYLQUERCETIN | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL273765 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL436338 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL18262 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL278972 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL276918 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL28079 | ZAPRINAST | IC50 | = | 66100.0 | nM | 4.18 |
| CHEMBL18487 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL18415 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL50 | QUERCETIN | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL18609 | — | IC50 | = | 470000.0 | nM | - |
| CHEMBL19047 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL19074 | PENTAACETYLQUERCETIN | IC50 | = | 355000.0 | nM | - |
| CHEMBL18701 | RO-201724 | IC50 | = | 1660000.0 | nM | - |