Assay Detail
Binding
CHEMBL824384
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Inhibition of alpha IIb beta-3 integrin binding to fibrinogen
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.72 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103214 | — | — | 1 | 6.07 |
| CHEMBL317887 | — | — | 1 | 5.77 |
| CHEMBL58763 | — | — | 1 | 5.77 |
| CHEMBL431829 | — | — | 1 | 5.28 |
| CHEMBL321332 | — | — | 1 | - |
| CHEMBL103089 | — | — | 1 | - |
| CHEMBL105553 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103214 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL317887 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL58763 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL431829 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL321332 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL103089 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL105553 | — | IC50 | > | 10000.0 | nM | - |