Assay Detail
Binding
CHEMBL824386
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of integrin alphaIIb-beta3 in platelet aggregation assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Binding model for nonpeptide antagonists of alpha(v)beta(3) integrin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.62 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59562 | — | — | 1 | 8.00 |
| CHEMBL123262 | — | — | 1 | 6.58 |
| CHEMBL151142 | — | — | 1 | 6.11 |
| CHEMBL332914 | — | — | 1 | 5.80 |
| CHEMBL86992 | — | — | 1 | - |
| CHEMBL351105 | — | — | 1 | - |
| CHEMBL53822 | — | — | 1 | - |
| CHEMBL82927 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59562 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL123262 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL151142 | — | IC50 | = | 776.0 | nM | 6.11 |
| CHEMBL332914 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL86992 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL351105 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL53822 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL82927 | — | IC50 | > | 10000.0 | nM | - |