Assay Detail
Binding
CHEMBL824387
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Binding affinity to resting form of alpha IIb/beta3 integrin by flow cytometry using fluorescein ligand L-726,745 displacement from human platelets.
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 27 | 7.44 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298655 | — | — | 1 | 8.96 |
| CHEMBL57040 | — | — | 1 | 8.89 |
| CHEMBL293601 | — | — | 1 | 8.68 |
| CHEMBL59562 | — | — | 1 | 8.62 |
| CHEMBL298589 | — | — | 1 | 8.51 |
| CHEMBL58328 | — | — | 1 | 8.47 |
| CHEMBL58713 | — | — | 1 | 8.21 |
| CHEMBL293588 | — | — | 1 | 7.96 |
| CHEMBL916 | TIROFIBAN | 4.0 | 1 | 7.89 |
| CHEMBL57134 | — | — | 1 | 7.89 |
| CHEMBL58790 | — | — | 1 | 7.82 |
| CHEMBL58675 | — | — | 1 | 7.64 |
| CHEMBL441438 | — | — | 1 | 7.33 |
| CHEMBL58618 | — | — | 1 | 7.31 |
| CHEMBL57886 | — | — | 1 | 7.30 |
| CHEMBL57191 | — | — | 1 | 7.22 |
| CHEMBL57881 | — | — | 1 | 7.08 |
| CHEMBL59020 | — | — | 1 | 7.08 |
| CHEMBL32960 | — | — | 1 | 6.92 |
| CHEMBL262194 | — | — | 1 | 6.92 |
| CHEMBL292663 | — | — | 1 | 6.68 |
| CHEMBL57192 | — | — | 1 | 6.47 |
| CHEMBL48371 | — | — | 1 | 6.19 |
| CHEMBL300097 | — | — | 1 | 6.17 |
| CHEMBL61353 | — | — | 1 | 5.64 |
| CHEMBL444573 | — | — | 1 | 5.51 |
| CHEMBL57094 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298655 | — | Kd | = | 1.1 | nM | 8.96 |
| CHEMBL57040 | — | Kd | = | 1.3 | nM | 8.89 |
| CHEMBL293601 | — | Kd | = | 2.1 | nM | 8.68 |
| CHEMBL59562 | — | Kd | = | 2.4 | nM | 8.62 |
| CHEMBL298589 | — | Kd | = | 3.1 | nM | 8.51 |
| CHEMBL58328 | — | Kd | = | 3.4 | nM | 8.47 |
| CHEMBL58713 | — | Kd | = | 6.1 | nM | 8.21 |
| CHEMBL293588 | — | Kd | = | 11.0 | nM | 7.96 |
| CHEMBL916 | TIROFIBAN | Kd | = | 13.0 | nM | 7.89 |
| CHEMBL57134 | — | Kd | = | 13.0 | nM | 7.89 |
| CHEMBL58790 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL58675 | — | Kd | = | 23.0 | nM | 7.64 |
| CHEMBL441438 | — | Kd | = | 47.0 | nM | 7.33 |
| CHEMBL58618 | — | Kd | = | 49.0 | nM | 7.31 |
| CHEMBL57886 | — | Kd | = | 50.0 | nM | 7.30 |
| CHEMBL57191 | — | Kd | = | 60.0 | nM | 7.22 |
| CHEMBL57881 | — | Kd | = | 84.0 | nM | 7.08 |
| CHEMBL59020 | — | Kd | = | 84.0 | nM | 7.08 |
| CHEMBL32960 | — | Kd | = | 120.0 | nM | 6.92 |
| CHEMBL262194 | — | Kd | = | 120.0 | nM | 6.92 |
| CHEMBL292663 | — | Kd | = | 210.0 | nM | 6.68 |
| CHEMBL57192 | — | Kd | = | 340.0 | nM | 6.47 |
| CHEMBL48371 | — | Kd | = | 640.0 | nM | 6.19 |
| CHEMBL300097 | — | Kd | = | 680.0 | nM | 6.17 |
| CHEMBL61353 | — | Kd | = | 2300.0 | nM | 5.64 |
| CHEMBL444573 | — | Kd | = | 3100.0 | nM | 5.51 |
| CHEMBL57094 | — | Kd | > | 1000.0 | nM | - |