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Assay Detail

CHEMBL824550

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of platelet glycoprotein alpha IIb beta-3 integrin in ELISA
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Integrin alpha-IIb/beta-3 (CHEMBL2093869)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Platelet glycoprotein IIbIIIa receptor (GPIIbIIIa) antagonists derived from amidinoindoles
Sall DJ, Arfsten AE, Berry DR, Denney ML, Harms CS, McCowan JR, Ray JK, Scarborough RM, Um SL, Utterback BG, Jakubowski JA
Bioorg Med Chem Lett (1996) 6 : 81 -86
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.44 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL318493 1 7.00
CHEMBL2371598 1 6.92
CHEMBL329571 1 6.82
CHEMBL95223 1 6.16
CHEMBL94814 1 5.01
CHEMBL265628 1 4.84
CHEMBL94337 1 4.64
CHEMBL95389 1 4.52
CHEMBL320670 1 4.32
CHEMBL95446 1 4.19
CHEMBL97565 1 -
CHEMBL97226 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL318493 IC50 = 100.0 nM 7.00
CHEMBL2371598 IC50 = 120.0 nM 6.92
CHEMBL329571 IC50 = 150.0 nM 6.82
CHEMBL95223 IC50 = 700.0 nM 6.16
CHEMBL94814 IC50 = 9800.0 nM 5.01
CHEMBL265628 IC50 = 14500.0 nM 4.84
CHEMBL94337 IC50 = 23000.0 nM 4.64
CHEMBL95389 IC50 = 30000.0 nM 4.52
CHEMBL320670 IC50 = 48000.0 nM 4.32
CHEMBL95446 IC50 = 64000.0 nM 4.19
CHEMBL97565 IC50 > 100000.0 nM -
CHEMBL97226 IC50 > 100000.0 nM -