Assay Detail
Binding
CHEMBL824551
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of platelet aggregation in human platelet-rich plasma alpha IIb beta-3 integrin to assess the selectivity for the alpha-v beta-3 over the GPIIb/IIIa integrin receptor
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Expert |
Target
Integrin alpha-V/beta-3 and alpha-IIb/beta 3 (CHEMBL2111443) ↗| Type | SELECTIVITY GROUP |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of nonpeptide integrin antagonists containing spirocyclic scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.42 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338865 | — | — | 1 | 6.51 |
| CHEMBL127525 | — | — | 1 | 6.31 |
| CHEMBL127377 | — | — | 1 | 6.10 |
| CHEMBL126925 | — | — | 1 | 6.08 |
| CHEMBL340703 | — | — | 1 | 6.00 |
| CHEMBL126416 | — | — | 1 | 5.85 |
| CHEMBL339751 | — | — | 1 | 5.25 |
| CHEMBL419795 | — | — | 1 | 5.15 |
| CHEMBL340309 | — | — | 1 | 5.14 |
| CHEMBL126341 | — | — | 1 | 5.14 |
| CHEMBL127492 | — | — | 1 | 5.08 |
| CHEMBL127133 | — | — | 1 | 5.08 |
| CHEMBL2111839 | — | — | 1 | 5.04 |
| CHEMBL126983 | — | — | 1 | 4.96 |
| CHEMBL339476 | — | — | 1 | 4.48 |
| CHEMBL338806 | — | — | 1 | 4.47 |
| CHEMBL435806 | — | — | 1 | - |
| CHEMBL338439 | — | — | 1 | - |
| CHEMBL338665 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338865 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL127525 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL127377 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL126925 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL340703 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL126416 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL339751 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL419795 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL340309 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL126341 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL127492 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL127133 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL2111839 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL126983 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL339476 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL338806 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL435806 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL338439 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL338665 | — | IC50 | > | 100000.0 | nM | - |