Assay Detail
Binding
CHEMBL824589
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cAMP Phosphodiesterase 3
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Novel cAMP PDE III inhibitors: 1,6-naphthyridin-2(1H)-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.23 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189 | MILRINONE | 4.0 | 1 | 6.44 |
| CHEMBL356805 | — | — | 1 | 6.22 |
| CHEMBL144706 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189 | MILRINONE | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL356805 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL144706 | — | IC50 | = | 960.0 | nM | 6.02 |