Assay Detail
Binding
CHEMBL824632
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Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding)
25
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.85 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442504 | — | — | 1 | 10.05 |
| CHEMBL408843 | — | — | 1 | 9.41 |
| CHEMBL385465 | — | — | 1 | 8.37 |
| CHEMBL2370553 | — | — | 1 | 7.80 |
| CHEMBL420167 | — | — | 1 | 7.75 |
| CHEMBL331259 | — | — | 1 | 7.70 |
| CHEMBL2370533 | — | — | 1 | 7.66 |
| CHEMBL433645 | — | — | 1 | 7.62 |
| CHEMBL266417 | — | — | 1 | 7.58 |
| CHEMBL268851 | — | — | 1 | 7.55 |
| CHEMBL434985 | — | — | 1 | 7.19 |
| CHEMBL333178 | — | — | 1 | 6.89 |
| CHEMBL122773 | — | — | 2 | 6.85 |
| CHEMBL124169 | — | — | 1 | 6.82 |
| CHEMBL123938 | — | — | 1 | 6.27 |
| CHEMBL407213 | — | — | 1 | 6.14 |
| CHEMBL333262 | — | — | 1 | 5.62 |
| CHEMBL333263 | — | — | 1 | 5.60 |
| CHEMBL334309 | — | — | 1 | 5.57 |
| CHEMBL331728 | — | — | 1 | 5.32 |
| CHEMBL420727 | — | — | 1 | 5.31 |
| CHEMBL436169 | — | — | 1 | 5.31 |
| CHEMBL332762 | — | — | 1 | 5.30 |
| CHEMBL432407 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442504 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL408843 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL385465 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL2370553 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL420167 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL331259 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL2370533 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL433645 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL266417 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL268851 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL434985 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL333178 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL122773 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL124169 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL122773 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL123938 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL407213 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL333262 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL333263 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL334309 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL331728 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL420727 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL436169 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL332762 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL432407 | — | Ki | = | 7000.0 | nM | 5.16 |