Assay Detail
Binding
CHEMBL824651
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at human PPAR alpha
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.30 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65458 | — | — | 1 | 7.21 |
| CHEMBL25259 | — | — | 1 | 6.83 |
| CHEMBL64972 | — | — | 1 | 6.20 |
| CHEMBL66206 | — | — | 1 | 6.14 |
| CHEMBL59132 | — | — | 1 | 6.11 |
| CHEMBL24458 | — | — | 1 | 6.04 |
| CHEMBL294807 | — | — | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65458 | — | EC50 | = | 61.9 | nM | 7.21 |
| CHEMBL25259 | — | EC50 | = | 149.5 | nM | 6.83 |
| CHEMBL64972 | — | EC50 | = | 625.0 | nM | 6.20 |
| CHEMBL66206 | — | EC50 | = | 717.0 | nM | 6.14 |
| CHEMBL59132 | — | EC50 | = | 771.0 | nM | 6.11 |
| CHEMBL24458 | — | EC50 | = | 922.0 | nM | 6.04 |
| CHEMBL294807 | — | EC50 | = | 2751.0 | nM | 5.56 |