Assay Detail
Binding
CHEMBL824656
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at human PPAR gamma
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.12 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59132 | — | — | 1 | 8.10 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 6.18 |
| CHEMBL25259 | — | — | 1 | 6.05 |
| CHEMBL24458 | — | — | 1 | 5.96 |
| CHEMBL65458 | — | — | 1 | 5.76 |
| CHEMBL66206 | — | — | 1 | 5.69 |
| CHEMBL408 | TROGLITAZONE | 4.0 | 1 | 5.65 |
| CHEMBL64972 | — | — | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59132 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 657.0 | nM | 6.18 |
| CHEMBL25259 | — | EC50 | = | 882.0 | nM | 6.05 |
| CHEMBL24458 | — | EC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL65458 | — | EC50 | = | 1716.0 | nM | 5.76 |
| CHEMBL66206 | — | EC50 | = | 2059.0 | nM | 5.69 |
| CHEMBL408 | TROGLITAZONE | EC50 | = | 2235.0 | nM | 5.65 |
| CHEMBL64972 | — | EC50 | = | 2751.0 | nM | 5.56 |