Assay Detail
Binding
CHEMBL824722
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Inhibitory potency against trypsin
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dibasic inhibitors of human mast cell tryptase. Part 1: synthesis and optimization of a novel class of inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 4.24 | 4.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310289 | — | — | 1 | 4.42 |
| CHEMBL46809 | — | — | 1 | 4.41 |
| CHEMBL43463 | — | — | 1 | 4.36 |
| CHEMBL80210 | — | — | 1 | 4.30 |
| CHEMBL77911 | — | — | 1 | 4.25 |
| CHEMBL79545 | — | — | 1 | 4.16 |
| CHEMBL46120 | — | — | 1 | 4.14 |
| CHEMBL408300 | — | — | 1 | 4.14 |
| CHEMBL75749 | — | — | 1 | 4.11 |
| CHEMBL310290 | — | — | 1 | 4.08 |
| CHEMBL79822 | — | — | 1 | - |
| CHEMBL78757 | — | — | 1 | - |
| CHEMBL309788 | — | — | 1 | - |
| CHEMBL80149 | — | — | 1 | - |
| CHEMBL77521 | — | — | 1 | - |
| CHEMBL79655 | — | — | 1 | - |
| CHEMBL76733 | — | — | 1 | - |
| CHEMBL306537 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310289 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL46809 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL43463 | — | Ki | = | 44000.0 | nM | 4.36 |
| CHEMBL80210 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL77911 | — | Ki | = | 56000.0 | nM | 4.25 |
| CHEMBL79545 | — | Ki | = | 70000.0 | nM | 4.16 |
| CHEMBL46120 | — | Ki | = | 73000.0 | nM | 4.14 |
| CHEMBL408300 | — | Ki | = | 72000.0 | nM | 4.14 |
| CHEMBL75749 | — | Ki | = | 78000.0 | nM | 4.11 |
| CHEMBL310290 | — | Ki | = | 84000.0 | nM | 4.08 |
| CHEMBL79822 | — | Ki | = | 162000.0 | nM | - |
| CHEMBL78757 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL309788 | — | Ki | = | 146000.0 | nM | - |
| CHEMBL80149 | — | Ki | = | 273000.0 | nM | - |
| CHEMBL77521 | — | Ki | = | 317000.0 | nM | - |
| CHEMBL79655 | — | Ki | = | 182000.0 | nM | - |
| CHEMBL76733 | — | Ki | = | 237000.0 | nM | - |
| CHEMBL306537 | — | Ki | = | 274000.0 | nM | - |