Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL824851

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effective concentration against human PPAR-alpha in Gal4 transactivation assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Peroxisome proliferator-activated receptor alpha (CHEMBL239)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activity.
Shi GQ, Dropinski JF, Zhang Y, Santini C, Sahoo SP, Berger JP, Macnaul KL, Zhou G, Agrawal A, Alvaro R, Cai TQ, Hernandez M, Wright SD, Moller DE, Heck JV, Meinke PT.
J Med Chem (2005) 48 : 5589 -5599
PubMed 16107159 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 13 7.98 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL363780 1 8.70
CHEMBL190603 1 8.70
CHEMBL366145 1 8.70
CHEMBL189110 1 8.70
CHEMBL425725 1 8.52
CHEMBL192500 1 8.10
CHEMBL190968 1 8.05
CHEMBL190334 1 7.82
CHEMBL192638 1 7.47
CHEMBL192609 1 7.43
CHEMBL426269 1 7.39
CHEMBL363006 1 7.24
CHEMBL192582 1 6.86

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL363780 EC50 = 2.0 nM 8.70
CHEMBL190603 EC50 = 2.0 nM 8.70
CHEMBL366145 EC50 = 2.0 nM 8.70
CHEMBL189110 EC50 = 2.0 nM 8.70
CHEMBL425725 EC50 = 3.0 nM 8.52
CHEMBL192500 EC50 = 8.0 nM 8.10
CHEMBL190968 EC50 = 9.0 nM 8.05
CHEMBL190334 EC50 = 15.0 nM 7.82
CHEMBL192638 EC50 = 34.0 nM 7.47
CHEMBL192609 EC50 = 37.0 nM 7.43
CHEMBL426269 EC50 = 41.0 nM 7.39
CHEMBL363006 EC50 = 57.0 nM 7.24
CHEMBL192582 EC50 = 138.0 nM 6.86