Assay Detail
Functional
CHEMBL824872
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MKN45 cancer cell line was determined after 144 hr
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-45 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Rational design, synthesis, and biological evaluation of bis(pyrimido[5,6,1-de]acridines) and bis(pyrazolo[3,4,5-kl]acridine-5-carboxamides) as new anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 9.11 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL187738 | — | — | 1 | 11.00 |
| CHEMBL186004 | — | — | 1 | 9.54 |
| CHEMBL362087 | — | — | 1 | 9.22 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 7.92 |
| CHEMBL189214 | — | — | 1 | 7.89 |
| CHEMBL188103 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL187738 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL186004 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL362087 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL189214 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL188103 | — | IC50 | = | 0.0028 | nM | - |