Assay Detail
Functional
CHEMBL824877
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-lipoxygenase mediated LTB4 synthesis in A-23187 simulated human whole blood
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-Lipoxygenase inhibitors: convenient synthesis of 4-[3-(4-heterocyclylphenylthio)phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.44 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191859 | — | — | 1 | 6.85 |
| CHEMBL427532 | — | — | 1 | 6.82 |
| CHEMBL195309 | — | — | 1 | 6.64 |
| CHEMBL362978 | — | — | 1 | 6.57 |
| CHEMBL192207 | — | — | 1 | 6.08 |
| CHEMBL195206 | — | — | 1 | 5.70 |
| CHEMBL191621 | — | — | 1 | - |
| CHEMBL370268 | — | — | 1 | - |
| CHEMBL365166 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191859 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL427532 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL195309 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL362978 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL192207 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL195206 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL191621 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL370268 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL365166 | — | IC50 | > | 1000.0 | nM | - |