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Assay Detail

CHEMBL824937

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of estrogen dependent human MCF-7 cell proliferation
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF-7
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Estrogen receptor (CHEMBL2093866)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs.
Tan Q, Blizzard TA, Morgan JD, Birzin ET, Chan W, Yang YT, Pai LY, Hayes EC, DaSilva CA, Warrier S, Yudkovitz J, Wilkinson HA, Sharma N, Fitzgerald PM, Li S, Colwell L, Fisher JE, Adamski S, Reszka AA, Kimmel D, DiNinno F, Rohrer SP, Freedman LP, Schaeffer JM, Hammond ML.
Bioorg Med Chem Lett (2005) 15 : 1675 -1681
PubMed 15745820 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 9.05 10.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL181248 1 10.15
CHEMBL368449 1 9.40
CHEMBL360315 1 9.30
CHEMBL359633 1 9.30
CHEMBL359671 1 9.22
CHEMBL180995 1 9.10
CHEMBL181404 1 9.05
CHEMBL181368 1 9.05
CHEMBL361005 1 8.96
CHEMBL369724 1 8.92
CHEMBL180146 1 8.85
CHEMBL433581 1 8.82
CHEMBL181936 1 8.82
CHEMBL178470 1 8.80
CHEMBL2113002 1 8.60
CHEMBL304552 1 8.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL181248 IC50 = 0.07 nM 10.15
CHEMBL368449 IC50 = 0.4 nM 9.40
CHEMBL360315 IC50 = 0.5 nM 9.30
CHEMBL359633 IC50 = 0.5 nM 9.30
CHEMBL359671 IC50 = 0.6 nM 9.22
CHEMBL180995 IC50 = 0.8 nM 9.10
CHEMBL181404 IC50 = 0.9 nM 9.05
CHEMBL181368 IC50 = 0.9 nM 9.05
CHEMBL361005 IC50 = 1.1 nM 8.96
CHEMBL369724 IC50 = 1.2 nM 8.92
CHEMBL180146 IC50 = 1.4 nM 8.85
CHEMBL433581 IC50 = 1.5 nM 8.82
CHEMBL181936 IC50 = 1.5 nM 8.82
CHEMBL178470 IC50 = 1.6 nM 8.80
CHEMBL2113002 IC50 = 2.5 nM 8.60
CHEMBL304552 IC50 = 3.0 nM 8.52