Assay Detail
Functional
CHEMBL824947
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit cell proliferation in KBV-1 tumor cell line; overexpress MDR1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.79 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70790 | — | — | 1 | 8.30 |
| CHEMBL361041 | — | — | 1 | 8.22 |
| CHEMBL187471 | — | — | 1 | 8.15 |
| CHEMBL186260 | — | — | 1 | 8.00 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.70 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70790 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL361041 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL187471 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL186260 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 440.0 | nM | 6.36 |