Assay Detail
Binding
CHEMBL825022
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Inhibitory activity against 3-phosphoglycerate kinase.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Novel bisphosphonate inhibitors of phosphoglycerate kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.22 | 6.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150751 | — | — | 1 | 6.08 |
| CHEMBL151887 | — | — | 1 | 6.06 |
| CHEMBL150369 | — | — | 1 | 6.02 |
| CHEMBL357952 | — | — | 1 | 6.01 |
| CHEMBL356655 | — | — | 1 | 6.00 |
| CHEMBL348186 | — | — | 1 | 6.00 |
| CHEMBL149734 | — | — | 1 | 5.97 |
| CHEMBL149786 | — | — | 1 | 5.94 |
| CHEMBL148974 | — | — | 1 | 5.93 |
| CHEMBL356436 | — | — | 1 | 5.89 |
| CHEMBL348433 | — | — | 1 | 5.87 |
| CHEMBL422133 | — | — | 1 | 5.75 |
| CHEMBL347337 | — | — | 1 | 5.70 |
| CHEMBL149264 | — | — | 1 | 5.44 |
| CHEMBL149115 | — | — | 1 | 5.10 |
| CHEMBL149058 | — | — | 1 | 5.08 |
| CHEMBL149129 | — | — | 1 | 5.03 |
| CHEMBL345538 | — | — | 1 | 4.97 |
| CHEMBL149998 | — | — | 1 | 4.80 |
| CHEMBL149943 | — | — | 1 | 4.77 |
| CHEMBL148780 | — | — | 1 | 4.16 |
| CHEMBL148792 | — | — | 1 | 4.14 |
| CHEMBL149729 | — | — | 1 | 4.11 |
| CHEMBL147415 | — | — | 1 | 4.06 |
| CHEMBL356430 | — | — | 1 | 4.06 |
| CHEMBL345282 | — | — | 1 | 4.05 |
| CHEMBL151547 | — | — | 1 | 4.00 |
| CHEMBL149333 | — | — | 1 | - |
| CHEMBL149219 | — | — | 1 | - |
| CHEMBL357982 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150751 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL151887 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL150369 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL357952 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL356655 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL348186 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL149734 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL149786 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL148974 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL356436 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL348433 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL422133 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL347337 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL149264 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL149115 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL149058 | — | IC50 | = | 8350.0 | nM | 5.08 |
| CHEMBL149129 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL345538 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL149998 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL149943 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL148780 | — | IC50 | = | 68800.0 | nM | 4.16 |
| CHEMBL148792 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL149729 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL147415 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL356430 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL345282 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL151547 | — | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL341829 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL148705 | — | IC50 | = | 182000.0 | nM | - |
| CHEMBL148654 | — | IC50 | = | 181000.0 | nM | - |
| CHEMBL150532 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL147362 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL358865 | — | IC50 | = | 193000.0 | nM | - |
| CHEMBL149259 | — | IC50 | = | 147000.0 | nM | - |
| CHEMBL357982 | — | IC50 | = | 163000.0 | nM | - |
| CHEMBL149219 | — | IC50 | = | 107000.0 | nM | - |
| CHEMBL149333 | — | IC50 | = | 138000.0 | nM | - |