Assay Detail
Functional
CHEMBL825076
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FGF-stimulated human umbilical vein endothelial cell proliferation
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Endothelial cell |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Fibroblast growth factor receptor (CHEMBL2095217) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Design, synthesis, and evaluation of orally active 4-(2,4-difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1-f][1,2,4]triazines as dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.94 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373365 | — | — | 1 | 9.00 |
| CHEMBL193306 | — | — | 1 | 8.40 |
| CHEMBL195398 | — | — | 1 | 8.34 |
| CHEMBL371373 | — | — | 1 | 8.33 |
| CHEMBL190980 | — | — | 1 | 8.28 |
| CHEMBL365318 | — | — | 1 | 8.19 |
| CHEMBL192101 | — | — | 1 | 8.18 |
| CHEMBL195847 | — | — | 1 | 8.14 |
| CHEMBL370515 | — | — | 1 | 8.12 |
| CHEMBL191913 | — | — | 1 | 8.04 |
| CHEMBL194498 | — | — | 1 | 7.68 |
| CHEMBL370023 | — | — | 1 | 7.48 |
| CHEMBL194872 | — | — | 1 | 7.36 |
| CHEMBL193136 | — | — | 1 | 7.34 |
| CHEMBL195771 | — | — | 1 | 7.27 |
| CHEMBL195903 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373365 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL193306 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL195398 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL371373 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL190980 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL365318 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL192101 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL195847 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL370515 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL191913 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL194498 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL370023 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL194872 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL193136 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL195771 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL195903 | — | IC50 | = | 130.0 | nM | 6.89 |