Assay Detail
Functional
CHEMBL825582
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (I329F)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Combination of molecular modeling, site-directed mutagenesis, and SAR studies to delineate the binding site of pyridopyrimidine antagonists on the human CCK1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.38 | 6.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363916 | — | — | 1 | 6.74 |
| CHEMBL189634 | — | — | 1 | 6.29 |
| CHEMBL366344 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363916 | — | IC50 | = | 183.2 | nM | 6.74 |
| CHEMBL189634 | — | IC50 | = | 514.3 | nM | 6.29 |
| CHEMBL366344 | — | IC50 | = | 801.2 | nM | 6.10 |