Assay Detail

CHEMBL826327

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Binding

Binding affinity for rat melanocortin-4 receptor

ChEMBL ↗

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Target

Melanocortin receptor 4 (CHEMBL2700) ↗

Open DB target context

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Melanocortin receptor 4 (CHEMBL2700) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Melanocortin receptor 4

CHEMBL2700

Anchored from Assay target.

Protein identity Melanocortin receptor 4

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Confidence	9 — Direct single protein target
Curated By	Expert

Target

Melanocortin receptor 4 (CHEMBL2700) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Discovery of a beta-MSH-derived MC-4R selective agonist.

Mayer JP, Hsiung HM, Flora DB, Edwards P, Smith DP, Zhang XY, Gadski RA, Heiman ML, Hertel JL, Emmerson PJ, Husain S, O'brien TP, Kahl SD, Smiley DL, Zhang L, Dimarchi RD, Yan LZ.
J Med Chem (2005) 48 : 3095 -3098
PubMed 15857110 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	10.05	10.05

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL415165	—	—	1	10.05

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL415165	—	Ki	=	0.09	nM	10.05