Assay Detail
Functional
CHEMBL826373
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FGF-dependent human umbilical vein endothelial cell proliferation
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Endothelial cell |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Fibroblast growth factor receptor (CHEMBL2095217) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast growth factor receptor-1 and vascular endothelial growth factor receptor-2 tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.92 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190161 | — | — | 1 | 9.40 |
| CHEMBL191070 | — | — | 1 | 9.30 |
| CHEMBL189995 | — | — | 1 | 8.72 |
| CHEMBL192856 | — | — | 1 | 8.70 |
| CHEMBL191023 | — | — | 1 | 8.57 |
| CHEMBL365727 | — | — | 1 | 8.40 |
| CHEMBL187396 | — | — | 1 | 8.36 |
| CHEMBL425363 | — | — | 1 | 8.22 |
| CHEMBL278472 | — | — | 1 | 8.22 |
| CHEMBL363551 | — | — | 1 | 7.92 |
| CHEMBL190389 | — | — | 1 | 7.85 |
| CHEMBL188087 | — | — | 1 | 7.82 |
| CHEMBL189584 | PD-173074 | — | 1 | 7.82 |
| CHEMBL189059 | — | — | 1 | 7.55 |
| CHEMBL365140 | — | — | 1 | 7.43 |
| CHEMBL339856 | — | — | 1 | 7.07 |
| CHEMBL189851 | — | — | 1 | 7.06 |
| CHEMBL188978 | — | — | 1 | 6.89 |
| CHEMBL191265 | — | — | 1 | 6.82 |
| CHEMBL190783 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190161 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL191070 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL189995 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL192856 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL191023 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL365727 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL187396 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL425363 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL278472 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL363551 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL190389 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL188087 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL189584 | PD-173074 | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL189059 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL365140 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL339856 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL189851 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL188978 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL191265 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL190783 | — | IC50 | = | 430.0 | nM | 6.37 |