Assay Detail
Binding
CHEMBL826378
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-1 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanocyte-stimulating hormone receptor (CHEMBL3795) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of piperazinebenzylamines as potent and selective agonists of the human melanocortin-4 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.64 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339053 | — | — | 1 | 5.82 |
| CHEMBL360716 | — | — | 1 | 5.82 |
| CHEMBL185035 | — | — | 1 | 5.68 |
| CHEMBL366706 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339053 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL360716 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL185035 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL366706 | — | Ki | = | 6000.0 | nM | 5.22 |