Assay Detail
Binding
CHEMBL826381
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]NDP-MSH from HEK293 cells expressing human melanocortin-5 receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of piperazinebenzylamines as potent and selective agonists of the human melanocortin-4 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.23 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366706 | — | — | 1 | 6.62 |
| CHEMBL365278 | — | — | 1 | 6.58 |
| CHEMBL360716 | — | — | 1 | 6.57 |
| CHEMBL185035 | — | — | 1 | 6.23 |
| CHEMBL339053 | — | — | 1 | 6.07 |
| CHEMBL340355 | — | — | 1 | 5.92 |
| CHEMBL183434 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366706 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL365278 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL360716 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL185035 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL339053 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL340355 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL183434 | — | Ki | = | 2300.0 | nM | 5.64 |