Assay Detail
Binding
CHEMBL826382
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Binding affinity against Opioid receptor delta 1 expressed in CHO cells using [3H]Naltrindole as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and opioid receptor binding properties of a highly potent 4-hydroxy analogue of naltrexone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.28 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL426084 | SAMIDORPHAN | 4.0 | 1 | 8.59 |
| CHEMBL370029 | — | — | 1 | 8.38 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 7.22 |
| CHEMBL195787 | — | — | 1 | 6.89 |
| CHEMBL195285 | — | — | 1 | 6.32 |
| CHEMBL56695 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL426084 | SAMIDORPHAN | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL370029 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL19019 | NALTREXONE | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL195787 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL195285 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL56695 | — | Ki | = | 550.0 | nM | 6.26 |