Assay Detail
Functional
CHEMBL826419
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Concentration required for inhibition of alpha-MSH stimulated cAMP production by 50%
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Cell line |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Piperazinebenzylamines as potent and selective antagonists of the human melanocortin-4 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.93 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186074 | — | — | 1 | 7.44 |
| CHEMBL186289 | — | — | 1 | 7.18 |
| CHEMBL186083 | — | — | 1 | 7.05 |
| CHEMBL364215 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186074 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL186289 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL186083 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL364215 | — | IC50 | = | 880.0 | nM | 6.06 |