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Assay Detail

CHEMBL826422

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Functional
In vitro inhibition of ADP-induced platelet aggregation in human platelet rich plasma
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Tissue Plasma
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery of new diphenyloxazole derivatives containing a pyrrolidine ring: orally active prostacyclin mimetics. Part 2.
Hattori K, Okitsu O, Tabuchi S, Taniguchi K, Nishio M, Koyama S, Seki J, Sakane K.
Bioorg Med Chem Lett (2005) 15 : 3279 -3283
PubMed 15935660 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.75 8.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL494 ILOPROST 4.0 1 8.60
CHEMBL190497 1 7.72
CHEMBL132589 1 7.22
CHEMBL371571 1 7.20
CHEMBL193058 1 6.85
CHEMBL268477 AP-227 1 6.82
CHEMBL192990 1 6.72
CHEMBL436131 1 6.19
CHEMBL191257 1 6.06
CHEMBL193018 1 6.00
CHEMBL190283 1 5.85
CHEMBL263564 1 5.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL494 ILOPROST IC50 = 2.5 nM 8.60
CHEMBL190497 IC50 = 19.0 nM 7.72
CHEMBL132589 IC50 = 60.0 nM 7.22
CHEMBL371571 IC50 = 63.0 nM 7.20
CHEMBL193058 IC50 = 140.0 nM 6.85
CHEMBL268477 AP-227 IC50 = 150.0 nM 6.82
CHEMBL192990 IC50 = 190.0 nM 6.72
CHEMBL436131 IC50 = 640.0 nM 6.19
CHEMBL191257 IC50 = 870.0 nM 6.06
CHEMBL193018 IC50 = 1000.0 nM 6.00
CHEMBL190283 IC50 = 1400.0 nM 5.85
CHEMBL263564 IC50 = 1500.0 nM 5.82