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Assay Detail

CHEMBL826424

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro antagonistic activity against MCF-7 cells was tested using proliferation assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Intermediate

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains.
Blizzard TA, DiNinno F, Morgan JD, Wu JY, Chen HY, Kim S, Chan W, Birzin ET, Yang YT, Pai LY, Zhang Z, Hayes EC, DaSilva CA, Tang W, Rohrer SP, Schaeffer JM, Hammond ML.
Bioorg Med Chem Lett (2004) 14 : 3865 -3868
PubMed 15225686 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 8.15 9.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL185114 1 9.22
CHEMBL81 RALOXIFENE 4.0 1 9.10
CHEMBL359774 1 8.72
CHEMBL304552 1 8.55
CHEMBL360802 1 8.49
CHEMBL362623 1 8.48
CHEMBL184679 1 8.42
CHEMBL184372 1 8.12
CHEMBL184431 1 7.95
CHEMBL362718 1 7.81
CHEMBL184491 1 7.68
CHEMBL185383 1 7.58
CHEMBL435696 1 7.38
CHEMBL185480 1 7.37
CHEMBL365484 1 7.37

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL185114 IC50 = 0.6 nM 9.22
CHEMBL81 RALOXIFENE IC50 = 0.8 nM 9.10
CHEMBL359774 IC50 = 1.9 nM 8.72
CHEMBL304552 IC50 = 2.8 nM 8.55
CHEMBL360802 IC50 = 3.2 nM 8.49
CHEMBL362623 IC50 = 3.3 nM 8.48
CHEMBL184679 IC50 = 3.8 nM 8.42
CHEMBL184372 IC50 = 7.5 nM 8.12
CHEMBL184431 IC50 = 11.3 nM 7.95
CHEMBL362718 IC50 = 15.6 nM 7.81
CHEMBL184491 IC50 = 21.0 nM 7.68
CHEMBL185383 IC50 = 26.3 nM 7.58
CHEMBL435696 IC50 = 42.0 nM 7.38
CHEMBL185480 IC50 = 42.3 nM 7.37
CHEMBL365484 IC50 = 42.5 nM 7.37