Assay Detail
Functional
CHEMBL826428
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Compound was tested for the cytotoxicity against KB-8-5 cell line expressing P-glycoprotein
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Tubulin inhibitors. Synthesis and biological activity of HTI-286 analogs with B-segment heterosubstituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.27 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL360439 | — | — | 1 | 8.74 |
| CHEMBL181650 | — | — | 1 | 8.66 |
| CHEMBL363453 | — | — | 1 | 8.46 |
| CHEMBL360165 | — | — | 1 | 7.36 |
| CHEMBL182270 | — | — | 1 | 7.26 |
| CHEMBL182109 | — | — | 1 | 7.03 |
| CHEMBL367814 | — | — | 1 | 7.02 |
| CHEMBL362056 | — | — | 1 | 6.23 |
| CHEMBL182526 | — | — | 1 | 6.16 |
| CHEMBL184777 | — | — | 1 | 5.76 |
| CHEMBL183335 | — | — | 1 | - |
| CHEMBL367578 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL360439 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL181650 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL363453 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL360165 | — | IC50 | = | 43.7 | nM | 7.36 |
| CHEMBL182270 | — | IC50 | = | 54.9 | nM | 7.26 |
| CHEMBL182109 | — | IC50 | = | 93.7 | nM | 7.03 |
| CHEMBL367814 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL362056 | — | IC50 | = | 588.8 | nM | 6.23 |
| CHEMBL182526 | — | IC50 | = | 691.8 | nM | 6.16 |
| CHEMBL184777 | — | IC50 | = | 1737.0 | nM | 5.76 |
| CHEMBL183335 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL367578 | — | IC50 | > | 3000.0 | nM | - |