Assay Detail
Functional
CHEMBL826430
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In vitro antiproliferative activity against human colon carcinoma HT-29 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of novel naphthocarbazoles as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.57 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370100 | REBECCAMYCIN | — | 1 | 6.52 |
| CHEMBL371377 | — | — | 1 | 6.08 |
| CHEMBL434930 | — | — | 1 | 5.87 |
| CHEMBL372031 | — | — | 1 | 5.87 |
| CHEMBL445923 | — | — | 1 | 5.54 |
| CHEMBL191680 | — | — | 1 | 5.43 |
| CHEMBL195541 | — | — | 1 | 5.42 |
| CHEMBL195531 | — | — | 1 | 5.26 |
| CHEMBL191757 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370100 | REBECCAMYCIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL371377 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL434930 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL372031 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL445923 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL191680 | — | IC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL195541 | — | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL195531 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL191757 | — | IC50 | = | 65700.0 | nM | 4.18 |