Assay Detail
Functional
CHEMBL826591
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of (10 uM) forskolin-mediated cAMP production in CHO cells expressing human Adenosine A3 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of novel N6-[4-(substituted)sulfonamidophenylcarbamoyl]adenosine-5'-uronamides as A3 adenosine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.48 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 8.66 |
| CHEMBL611095 | — | — | 1 | 7.38 |
| CHEMBL611091 | — | — | 1 | 7.30 |
| CHEMBL608755 | — | — | 1 | 7.26 |
| CHEMBL611104 | — | — | 1 | 7.19 |
| CHEMBL265587 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431733 | NAMODENOSON | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL611095 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL611091 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL608755 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL611104 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL265587 | — | IC50 | = | 81.0 | nM | 7.09 |