Assay Detail
Binding
CHEMBL826973
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Inhibition of 5-lipoxygenase activity in human whole blood assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.90 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL187637 | — | — | 1 | 7.32 |
| CHEMBL360202 | — | — | 1 | 7.24 |
| CHEMBL186125 | — | — | 1 | 7.17 |
| CHEMBL185825 | — | — | 1 | 7.05 |
| CHEMBL444083 | — | — | 1 | 7.05 |
| CHEMBL187264 | — | — | 1 | 7.02 |
| CHEMBL185905 | — | — | 1 | 6.73 |
| CHEMBL188021 | — | — | 1 | 6.71 |
| CHEMBL425358 | — | — | 1 | 6.67 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL187637 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL360202 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL186125 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL185825 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL444083 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL187264 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL185905 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL188021 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL425358 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL93 | ZILEUTON | IC50 | = | 873.0 | nM | 6.06 |