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Assay Detail

CHEMBL826997

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro dissociation constant for heat shock 90 kDa protein alpha
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Heat shock protein HSP 90-alpha (CHEMBL3880)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.
Kreusch A, Han S, Brinker A, Zhou V, Choi HS, He Y, Lesley SA, Caldwell J, Gu XJ.
Bioorg Med Chem Lett (2005) 15 : 1475 -1478
PubMed 15713410 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 2 6.36 6.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL360563 1 6.55
CHEMBL178130 1 6.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL360563 Kd = 280.0 nM 6.55
CHEMBL178130 Kd = 680.0 nM 6.17