Assay Detail
Binding
CHEMBL827045
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Inhibition of Aurora kinase A
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.25 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192928 | — | — | 1 | 8.30 |
| CHEMBL363160 | PHA-680632 | — | 1 | 7.57 |
| CHEMBL191816 | — | — | 1 | 7.39 |
| CHEMBL363857 | — | — | 1 | 7.19 |
| CHEMBL191402 | — | — | 1 | 7.00 |
| CHEMBL192575 | — | — | 1 | 6.89 |
| CHEMBL190252 | — | — | 1 | 6.85 |
| CHEMBL427170 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192928 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL363160 | PHA-680632 | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL191816 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL363857 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL191402 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL192575 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL190252 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL427170 | — | IC50 | = | 160.0 | nM | 6.80 |