Assay Detail
Binding
CHEMBL827094
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of human Phosphodiesterase 5
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.69 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185304 | — | — | 1 | 5.07 |
| CHEMBL185208 | — | — | 1 | 5.02 |
| CHEMBL427505 | — | — | 1 | 4.90 |
| CHEMBL184945 | — | — | 1 | 4.71 |
| CHEMBL185370 | — | — | 1 | 4.28 |
| CHEMBL361469 | — | — | 1 | 4.17 |
| CHEMBL185588 | — | — | 1 | - |
| CHEMBL366149 | — | — | 1 | - |
| CHEMBL363084 | — | — | 1 | - |
| CHEMBL427513 | — | — | 1 | - |
| CHEMBL182617 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185304 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL185208 | — | IC50 | = | 9470.0 | nM | 5.02 |
| CHEMBL427505 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL184945 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL185370 | — | IC50 | = | 52400.0 | nM | 4.28 |
| CHEMBL361469 | — | IC50 | = | 68400.0 | nM | 4.17 |
| CHEMBL185588 | — | IC50 | > | 101000.0 | nM | - |
| CHEMBL366149 | — | IC50 | > | 67300.0 | nM | - |
| CHEMBL363084 | — | IC50 | > | 101000.0 | nM | - |
| CHEMBL427513 | — | IC50 | > | 50700.0 | nM | - |
| CHEMBL182617 | — | IC50 | > | 84900.0 | nM | - |