Assay Detail
Binding
CHEMBL827103
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human matrix metalloprotease-14
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N-i-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.42 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | 3.0 | 1 | 9.52 |
| CHEMBL362651 | — | — | 1 | 8.11 |
| CHEMBL514138 | CGS-27023A | — | 1 | 8.05 |
| CHEMBL179288 | — | — | 1 | 8.01 |
| CHEMBL369317 | — | — | 1 | - |
| CHEMBL181244 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75094 | PRINOMASTAT | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL362651 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL179288 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL369317 | — | IC50 | > | 300.0 | nM | - |
| CHEMBL181244 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL181244 | — | IC50 | > | 833.0 | nM | - |