Assay Detail
Binding
CHEMBL827144
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Binding affinity for rat Dopamine receptor D3
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as selective alpha(1d)-adrenergic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.61 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13647 | BMY-7378 | — | 1 | 8.51 |
| CHEMBL299691 | — | — | 1 | 8.28 |
| CHEMBL556313 | — | — | 1 | 8.09 |
| CHEMBL193620 | — | — | 1 | 7.64 |
| CHEMBL57546 | — | — | 1 | 7.04 |
| CHEMBL98241 | — | — | 1 | 6.92 |
| CHEMBL192099 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13647 | BMY-7378 | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL299691 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL556313 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL193620 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL57546 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL98241 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL192099 | — | Ki | = | 160.0 | nM | 6.80 |