Assay Detail
Binding
CHEMBL827146
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity for 5-HT transporter
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.44 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 8.04 |
| CHEMBL298406 | ECOPIPAM | 3.0 | 1 | 7.10 |
| CHEMBL180059 | — | — | 1 | 6.86 |
| CHEMBL368482 | — | — | 1 | 6.27 |
| CHEMBL361179 | — | — | 1 | 6.08 |
| CHEMBL368926 | — | — | 1 | 5.53 |
| CHEMBL366839 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL298406 | ECOPIPAM | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL180059 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL368482 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL361179 | — | Ki | = | 842.0 | nM | 6.08 |
| CHEMBL368926 | — | Ki | = | 2950.0 | nM | 5.53 |
| CHEMBL366839 | — | Ki | = | 6220.0 | nM | 5.21 |