Assay Detail
Binding
CHEMBL827148
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Inhibitory activity against calcineurin phosphatase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A locally active antiinflammatory macrolide (MLD987) for inhalation therapy of asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.20 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 7.46 |
| CHEMBL411735 | — | — | 1 | 7.41 |
| CHEMBL265123 | — | — | 1 | 6.73 |
| CHEMBL1370 | BUDESONIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269732 | TACROLIMUS ANHYDROUS | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL411735 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL265123 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL1370 | BUDESONIDE | Ki | - | nM | - |