Assay Detail
Binding
CHEMBL827162
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Inhibitory concentration against maize histone deacetylase 2
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Zea mays |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.92 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.15 |
| CHEMBL274445 | TRAPOXIN A | — | 1 | 8.00 |
| CHEMBL2000089 | TRAPOXIN B | — | 1 | 8.00 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.30 |
| CHEMBL279636 | — | — | 1 | 6.96 |
| CHEMBL192098 | — | — | 1 | 6.70 |
| CHEMBL192870 | — | — | 1 | 6.60 |
| CHEMBL145116 | — | — | 1 | 6.57 |
| CHEMBL145685 | — | — | 1 | 6.55 |
| CHEMBL365535 | — | — | 1 | 6.44 |
| CHEMBL191852 | — | — | 1 | 6.38 |
| CHEMBL192199 | — | — | 1 | 6.27 |
| CHEMBL191623 | — | — | 1 | 6.24 |
| CHEMBL365372 | — | — | 1 | 6.17 |
| CHEMBL370253 | — | — | 1 | 5.75 |
| CHEMBL356769 | TUBACIN | — | 1 | 5.70 |
| CHEMBL364970 | — | — | 1 | 5.68 |
| CHEMBL142441 | — | — | 1 | 5.28 |
| CHEMBL371806 | — | — | 1 | 5.15 |
| CHEMBL415533 | — | — | 1 | 5.10 |
| CHEMBL145099 | — | — | 1 | 4.99 |
| CHEMBL191089 | — | — | 1 | 4.66 |
| CHEMBL145028 | — | — | 1 | 4.62 |
| CHEMBL145531 | — | — | 1 | 4.60 |
| CHEMBL189381 | — | — | 1 | 4.58 |
| CHEMBL192960 | — | — | 1 | 4.54 |
| CHEMBL192533 | — | — | 1 | 4.45 |
| CHEMBL371779 | — | — | 1 | 4.31 |
| CHEMBL192557 | — | — | 1 | - |
| CHEMBL433 | VALPROATE SODIUM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL274445 | TRAPOXIN A | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2000089 | TRAPOXIN B | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL279636 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL192098 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL192870 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL145116 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL145685 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL365535 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL191852 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL192199 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL191623 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL365372 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL370253 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL356769 | TUBACIN | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL364970 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL142441 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL371806 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL415533 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL145099 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL191089 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL145028 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL145531 | — | IC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL189381 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL192960 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL192533 | — | IC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL371779 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL192557 | — | IC50 | = | 176000.0 | nM | - |
| CHEMBL433 | VALPROATE SODIUM | IC50 | = | 128000.0 | nM | - |