Assay Detail
Binding
CHEMBL827166
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Inhibitory activity against recombinant human I-kappa-B-kinase beta
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL1991) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of novel IKK-beta inhibitors. Part 2: Improvement of in vitro activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.14 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185153 | — | — | 1 | 6.64 |
| CHEMBL182315 | — | — | 1 | 6.64 |
| CHEMBL181358 | — | — | 1 | 6.52 |
| CHEMBL182312 | — | — | 1 | 6.48 |
| CHEMBL362249 | — | — | 1 | 6.28 |
| CHEMBL181914 | — | — | 1 | 5.21 |
| CHEMBL363226 | — | — | 1 | 5.19 |
| CHEMBL182966 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185153 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL182315 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL181358 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL182312 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL362249 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL181914 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL363226 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL182966 | — | IC50 | > | 20.0 | nM | - |