Assay Detail
Binding
CHEMBL827170
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Inhibition of matrix metalloprotease-2
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.09 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440498 | CTS-1027 | 2.0 | 1 | 9.66 |
| CHEMBL180275 | — | — | 1 | 9.64 |
| CHEMBL361527 | — | — | 2 | 9.40 |
| CHEMBL180616 | — | — | 1 | 9.37 |
| CHEMBL178509 | — | — | 1 | 8.80 |
| CHEMBL178163 | — | — | 1 | 8.74 |
| CHEMBL359716 | — | — | 1 | 8.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440498 | CTS-1027 | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL180275 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL361527 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL180616 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL178509 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL361527 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL178163 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL359716 | — | Ki | = | 4.7 | nM | 8.33 |