Assay Detail
Binding
CHEMBL827171
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of matrix metalloprotease-3
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.38 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440498 | CTS-1027 | 2.0 | 1 | 8.03 |
| CHEMBL361527 | — | — | 2 | 7.04 |
| CHEMBL178163 | — | — | 1 | 6.96 |
| CHEMBL180616 | — | — | 1 | 6.37 |
| CHEMBL359716 | — | — | 1 | 5.89 |
| CHEMBL180275 | — | — | 1 | 5.50 |
| CHEMBL178509 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440498 | CTS-1027 | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL361527 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL178163 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL180616 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL361527 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL359716 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL180275 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL178509 | — | Ki | = | 4500.0 | nM | 5.35 |