Assay Detail
Binding
CHEMBL827205
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Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Methanosarcina thermophila |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.45 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.22 |
| CHEMBL68253 | SULFAMATE | — | 1 | 7.05 |
| CHEMBL266240 | — | — | 1 | 6.92 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 6.89 |
| CHEMBL7092 | — | — | 1 | 6.85 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.85 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.85 |
| CHEMBL6852 | — | — | 1 | 6.77 |
| CHEMBL266026 | — | — | 1 | 6.75 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 6.72 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 6.70 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL7087 | — | — | 1 | 6.57 |
| CHEMBL268177 | — | — | 1 | 6.55 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 6.46 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 6.39 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 6.08 |
| CHEMBL6853 | — | — | 1 | 6.01 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 5.99 |
| CHEMBL6724 | — | — | 1 | 5.76 |
| CHEMBL7204 | — | — | 1 | 5.66 |
| CHEMBL355001 | SULFAMIDE | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL68253 | SULFAMATE | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL266240 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL865 | VALDECOXIB | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL7092 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL118 | CELECOXIB | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL6852 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL266026 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL7087 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL268177 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL419 | MAFENIDE | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL6853 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL6724 | — | Ki | = | 1720.0 | nM | 5.76 |
| CHEMBL7204 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL355001 | SULFAMIDE | Ki | = | 69860.0 | nM | 4.16 |