Assay Detail
Binding
CHEMBL827209
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]iodosulpiride binding to human Dopamine receptor D3
16
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.23 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193639 | — | — | 2 | 8.96 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.36 |
| CHEMBL363581 | — | — | 1 | 8.07 |
| CHEMBL366164 | — | — | 1 | 7.82 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 7.80 |
| CHEMBL194659 | — | — | 1 | 7.51 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.37 |
| CHEMBL364270 | — | — | 1 | 7.35 |
| CHEMBL329566 | — | — | 1 | 7.08 |
| CHEMBL193435 | — | — | 1 | 7.02 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.62 |
| CHEMBL435301 | — | — | 1 | 6.60 |
| CHEMBL195706 | — | — | 1 | 6.53 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 5.55 |
| CHEMBL654 | MIRTAZAPINE | 4.0 | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193639 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL363581 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL366164 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL85 | RISPERIDONE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL193639 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL194659 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL715 | OLANZAPINE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL364270 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL329566 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL193435 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL42 | CLOZAPINE | Ki | = | 242.0 | nM | 6.62 |
| CHEMBL435301 | — | Ki | = | 251.0 | nM | 6.60 |
| CHEMBL195706 | — | Ki | = | 293.0 | nM | 6.53 |
| CHEMBL6437 | MIANSERIN | Ki | = | 2841.0 | nM | 5.55 |
| CHEMBL654 | MIRTAZAPINE | Ki | = | 5723.0 | nM | 5.24 |