Assay Detail
Binding
CHEMBL827210
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Inhibition of [3H]7-OH-DPAT binding to Dopamine D3 receptor expressed in Sf9 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Spodoptera frugiperda |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.33 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367045 | — | — | 1 | 8.08 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.75 |
| CHEMBL179557 | — | — | 1 | 7.62 |
| CHEMBL180319 | — | — | 1 | 7.60 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.41 |
| CHEMBL178564 | — | — | 1 | 7.05 |
| CHEMBL179775 | — | — | 1 | 6.65 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367045 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL179557 | — | Ki | = | 24.2 | nM | 7.62 |
| CHEMBL180319 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL715 | OLANZAPINE | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL178564 | — | Ki | = | 88.6 | nM | 7.05 |
| CHEMBL179775 | — | Ki | = | 224.0 | nM | 6.65 |
| CHEMBL42 | CLOZAPINE | Ki | = | 319.0 | nM | 6.50 |