Assay Detail
Binding
CHEMBL827211
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]DAMGO binding to Opioid receptor mu 1
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, chemical synthesis, and biological evaluation of thiosaccharide analogues of morphine- and codeine-6-glucuronide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 4.97 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70 | MORPHINE | 4.0 | 1 | 5.96 |
| CHEMBL363976 | — | — | 1 | 5.27 |
| CHEMBL365900 | — | — | 1 | 5.27 |
| CHEMBL361491 | — | — | 2 | 5.11 |
| CHEMBL361921 | — | — | 1 | 5.06 |
| CHEMBL1330 | MORPHINE GLUCURONIDE | 2.0 | 1 | 4.89 |
| CHEMBL438373 | — | — | 1 | 4.19 |
| CHEMBL434900 | — | — | 1 | 4.00 |
| CHEMBL264244 | — | — | 1 | - |
| CHEMBL187225 | — | — | 1 | - |
| CHEMBL434723 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70 | MORPHINE | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL363976 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL365900 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL361491 | — | Ki | = | 7800.0 | nM | 5.11 |
| CHEMBL361921 | — | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL1330 | MORPHINE GLUCURONIDE | Ki | = | 12900.0 | nM | 4.89 |
| CHEMBL438373 | — | Ki | = | 64000.0 | nM | 4.19 |
| CHEMBL434900 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL264244 | — | Ki | = | 305000.0 | nM | - |
| CHEMBL361491 | — | Ki | = | 165000.0 | nM | - |
| CHEMBL187225 | — | Ki | = | 463000.0 | nM | - |
| CHEMBL434723 | — | Ki | = | 127000.0 | nM | - |