Assay Detail
Binding
CHEMBL827219
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In vitro inhibitory activity against matrix metalloprotease-13
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Benzodiazepine inhibitors of the MMPs and TACE. Part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.54 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366257 | — | — | 1 | 8.15 |
| CHEMBL183732 | — | — | 1 | 7.92 |
| CHEMBL184007 | — | — | 1 | 7.77 |
| CHEMBL359969 | — | — | 1 | 7.77 |
| CHEMBL365892 | — | — | 1 | 7.72 |
| CHEMBL185375 | — | — | 1 | 7.70 |
| CHEMBL183924 | — | — | 1 | 7.70 |
| CHEMBL183735 | — | — | 1 | 7.68 |
| CHEMBL184119 | — | — | 1 | 7.55 |
| CHEMBL184168 | — | — | 1 | 7.50 |
| CHEMBL363758 | — | — | 1 | 7.48 |
| CHEMBL184943 | — | — | 1 | 7.38 |
| CHEMBL184745 | — | — | 1 | 7.33 |
| CHEMBL363938 | — | — | 1 | 7.28 |
| CHEMBL183228 | — | — | 1 | 7.17 |
| CHEMBL97790 | — | — | 1 | 7.11 |
| CHEMBL183404 | — | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366257 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL183732 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL184007 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL359969 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL365892 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL185375 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL183924 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL183735 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL184119 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL184168 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL363758 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL184943 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL184745 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL363938 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL183228 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL97790 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL183404 | — | IC50 | = | 97.0 | nM | 7.01 |